The Fortune 500® is an annual list compiled and published by Fortune magazine that ranks the top 500 U.S. closely held and public corporations. The list includes publicly and privately held companies for which revenues are publicly available. The first Fortune 500 list was published in 1955. 

For 2015, 4 companies headquartered in the Toledo Region made the list.

#25 With more than 125 years in the energy business, Marathon Petroleum Corporation (MPC) is one of the largest petroleum product refiners, marketers and transporters in the United States. MPC operates an integrated refining, marketing and transportation system concentrated primarily in the Midwest, Southeast, Northeast and Gulf Coast regions of the U.S.  Headquartered in Findlay, Ohio, MPC has approximately 45,340 employees and ranks in the top 25 of the Fortune 500®. 

#399 O-I is the world's leading glass-packaging maker. O-I creates recyclable glass containers for many of the world’s best-loved brands. Founded in 1903, the company has 75 plants in 21 countries . Based in Perrysburg, Ohio, the company employs 21,100 worldwide and holds over 1,900 worldwide patents.

#410 Dana Corporation is a global leader in the supply of highly engineered driveline, sealing, and thermal-management technologies that improve the efficiency and performance of vehicles with both conventional and alternative-energy powertrains.   Founded in 1904 and based in Maumee, Ohio, the company employs 23,000 people in 26 countries on six continents.

#498 Owens Corning is the world leader in glass fiber technology, and it made legal history as  the first company to trademark a color.   Founded in 1938, the company employs 14,000 people at its plants and technical centers in 25 countries.  Headquartered in Toledo, Ohio, Owens Corning has ranked on the Fortune 500® list for 60 consecutive years thanks to their three market-leading businesses: Insulation, Roofing and Composites.

Additionally, Fortune 1000® companies headquartered in the region include The AndersonsCooper Tire, Health Care REIT and La-Z-Boy.